When a London room runs late, do you change your set because people are tired?

Late rooms make me wonder how much an act should adapt before they’ve even started. If you’re on near the end and the audience has already watched a lot of comedy, do you tighten the setup and get to the first laugh faster, swap in material you know is punchier, or trust the set you planned? I can’t tell when that’s sensible room-reading and when it’s just panicking because it’s 10:45.